Drug Interactions

Medications that should be avoided by women who are taking tamoxifen for the prevention of breast cancer, either primary or recurrence, are listed in a review published in the Journal of Clinical Oncology.

Concomitant use not recommended  Potassium sparing diuretics or potassium supplements Angiotensin II receptor antagonists attenuate diuretic induced potassium loss.

A number of medicinal products are known to interact with glucose metabolism.

Raloxifene hydrochloride is a selective oestrogen-receptor modulator (SERM) that has been approved for use in the prevention and treatment of osteoporosis in postmenopausal women.

Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase, whereas non-selective NSAIDs substantially inhibit both COX-1 and COX-2.

Coadministration of methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs) can cause a pharmacokinetic interaction and a subsequent increase in blood methotrexate concentrations.

Sildenafil, vardenafil and tadalafil are primarily metabolised by hepatic enzymes via cytochrome CYP3A4 with some contribution from isoform CYP2C9 for sildenafil and from CYP3A5 and CYP2C for vardenafil.