Company: TEVA Pharmaceuticals Ireland.
Legal category: Prescription. GMS. Sport Permitted.
Active ingredient: Alfuzosin hydrochloride10mg.
Description: White, round, bevelled-edges, prolonged releasetablet.
Presentation: 30, €18.78.
Indications: Moderate to severe functional symptoms of benignprostatic hyperplasia (BPH).
Pharmacology: Alfuzosin is an orally acting quinazolin derivative,which selectively blocks post-synaptic alpha-1-receptors and thus relaxessmooth muscle and improves urinary flow.
Dosage: Adult: 10mg daily, taken as immediately after the same meal each day. Tablet should be swallowed whole with a sufficient amount of fluid (e.g. a glass of water) and initial dose taken at bedtime. Elderly: As per adults. Children: Not recommended.
Contraindications: Hypersensitivity to alfuzosin, other quinazolines (e.g. terazosin, doxazosin) or to any of the excipients. Conditions with orthostatic hypotension. Hepatic insufficiency. Severe renal impairment (cc<30ml/min); not recommended (nodata).
Special precautions: Transient postural hypotension may develop within a few hours of administration; lie down until the symptoms have totally disappeared (inform patient). Caution: Patients who developed pronounced hypotension with other alpha-1-blockers, acute cardiac failure. Hypersensitivity to other alpha-1-blockers, initiate treatment gradually. If angina pectoris recurs or worsens, discontinue. The ‘Intraoperative Floppy Iris Syndrome’ (IFIS, a variant of small pupil syndrome) has been observed during cataract surgery (inform surgeon of current or past treatment).Contains lactose.
Drug interactions: Not recommended: Other alpha-1-receptor blocking agents, potent CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycine, erythromycine). Caution: Antihypertensive agents (monitor BP), nitrates. Anaesthetics, withdraw tablets 24 hours previously.
Adverse drug reactions: Dizziness, headache, vertigo, malaise, postural hypotension, nausea, GI disorders, asthenia.
Full prescribing information and references available from TEVA Pharmaceuticals Ireland. Telephone: 1800 201700.