Tibolone (Livial) is a synthetic hormone therapy that is licensed as a first-line treatment for menopausal symptoms and a second-line therapy for prevention of osteoporosis in postmenopausal women who are at high risk of future fracture. There are limited clinical trial data and conflicting epidemiological evidence regarding the risk of breast cancer associated with tibolone [...]
New phase III study of Avastin in advanced breast cancer meets its primary endpoint of increasing Progression Free Survival. Roche has announced that the RIBBON-1 study met its primary endpoint of increasing progression-free survival compared to chemotherapy alone, as determined by the treating physicians. RIBBON-1 is a double blind phase III study in first-line metastatic [...]
Pfizer wish to announce results from a first planned analysis of the TEAM (Tamoxifen, Exemestane, Adjuvant, Multicentre) trial conducted in postmenopausal women with hormone sensitive early breast cancer. While tamoxifen blocks the action of oestrogen by binding to the oestrogen receptor, exemestane (Aromasin) inhibits aromatase, an enzyme that catalyses the conversion of androgens to estrogens. [...]
Company: TEVA Pharmaceuticals Ireland. Legal category: Prescription. HT. Sport permitted. Active ingredient: Bicalutamide 50mg. Description: White to off-white biconvex, film-coated tablet, debossed with 93 on one side and 220 on the other. Indications: Advanced prostatic carcinoma in combination with luteinising hormone-releasing hormone (LHRH) analogue or surgical castration. Pharmacology: Bicalutamide is a non-steroidal antiandrogen without any [...]
Company: Rowex Ltd. Legal category: Prescription. GMS. Sport permitted. Active ingredient: Donepezil HCl 5mg, 10mg. Description: Respectively, white (diameter 7mm) or yellow (diameter 9mm) film-coated tablets. 10mg tablets have a score line and can be divided into equal halves. Presentation: 5mg-28, €45.65; 10mg-28, €64.01. Indications: Symptomatic treatment of mild to moderately severe Alzheimer’s dementia. Pharmacology: [...]
Company: Actavis Ireland Ltd. Legal category: Prescription. GMS. Sport permitted. Active ingredient: Alendronic acid 70mg. Description: Round, white, biconvex tablets marked 70 on one side. Presentation: Available on request Indications: Postmenopausal osteoporosis. Alendronic acid reduces the risk of vertebral and hip fractures. Pharmacology: Alendronate monosodium trihydrate is a bisphosphonate that inhibits osteoclastic bone resorption with [...]
Company: Actavis Ireland Ltd. Legal category: Prescription. GMS. Sport permitted. Active ingredient: Clarithromycin 250mg, 500mg. Description: Yellow, oval, biconvex film-coated tablets marked with 250 and 500 respectively on one side and CL on the other side. Presentation: Prices available on request. Indications: Infections caused by susceptible organisms. Lower RTIs (e.g. bronchitis, pneumonia), upper RTIs (e.g. [...]
Company: Ratiopharm direct. Legal category: Prescription. HT. Sport prohibited. Active ingredient: Filgrastim 60MIU/ml. Description: Clear, colourless solution for injection or infusion in pre-filled syringes. Presentation: 30 MIU/0.5ml-5, €448.37; 48MIU/0.8 ml-5, € 714.96. Indications: Reduction in duration of neutropenia and incidence of febrile neutropenia after established cytotoxic chemotherapy; reduction in duration of neutropenia after myeloablative therapy [...]
Company: Roche Products (Ireland) Ltd. Legal category: Hospital only. Sport pending. Active ingredient: Tocilizumab 20mg/ml. Description: Concentrate for solution for infusion in vials. Presentation: 80mg/4ml, €167.53; 200mg/10ml, €418.82; 400mg/20ml, €837.65. Indications: In combination with methotrexate (MTX), for the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients who have either responded inadequately [...]
Company: Ranbaxy UK. Legal category: Prescription. GMS. Sport permitted. Active ingredient: Venlafaxine 37.5mg, 75mg. (eq. to 42.413mg venlafaxine HCl). Description: Peach coloured, mottled, uncoated, shield-shaped tablets debossed with V and 2 or V and 4, respectively, on one side and plain on the other. Presentations: 37.5mg-56, €19.94; 75mg-56, €33.26. Indications: Treatment of major depressive disorder [...]
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