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March 28, 2015

Peripheral Arterial Disease

  “The identification and appropriate management of this often unidentified, high risk patient group, represents a significant opportunity in general practice to improve survival and reduce the risk of heart attack and stroke.”1 Summary Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, most commonly presents in the lower limbs, but also serves as an […]

Eligard (leuprorelin acetate depot injection) – Risk of lack of efficacy due to incorrect reconstitution and administration process

Following identification of a signal of administration errors with Eligard and concerns that such errors may impact on clinical efficacy, this issue was reviewed at EU level by the Pharmacovigilance Risk Assessment Committee (PRAC). A cumulative review of reported global cases identified errors related to storage, preparation and reconstitution of Eligard. Appropriate reconstitution is a […]

DuoResp Spiromax

Company: Teva Pharmaceuticals Ireland. Legal category: Prescription. GMS. Sport restricted beta2 agonists. Active ingredients: Budesonide/formoterol (fumarate dihydrate) 160/4.5mcg, 320/9mcg per delivered dose. Description: Inhalation powder. Presentation: 160/4.5mcg-120 dose unit, €34.80; 320/9mcg-60 dose unit, €34.12. Indications: Regular treatment of asthma in adults where use of a combination (inhaled corticosteroid and long-acting β2 adrenoceptor agonist) is appropriate. […]


  Company: Novartis Consumer Health. Legal category: Pharmacy only. Sport permitted. Active ingredients: Acetylsalicylic acid (aspirin)/paracetamol/caffeine 250/250/65mg. Description: White, oblong-shaped, film-coated tablet marked E. Presentation: 10, €2.66; 20, €4.66. Indications: Acute treatment of headache and migraine attacks with or without aura. Pharmacology: Acetylsalicylic acid (ASA) has analgesic, antipyretic and antiinflammatory properties, primarily due to the […]

Opsumit ▼

Company: Actelion Pharmaceuticals UK Ltd. Legal category: Prescription. High Tech. Sport permitted. Active ingredient: Macitentan 10mg. Description: Round, biconvex, white, film-coated tablets marked 10. Presentation: 28, price available on request. Indication: Long-term treatment of pulmonary arterial hypertension (WHO Functional Class II to III). As monotherapy or in combination. Pharmacology: Macitentan is a potent endothelin receptor […]


Company: Consilient Health Ltd. Legal category: OTC. Sport permitted. GMS reimbursement from 1st April 2015. Active ingredient: Levonorgestrel 1500mcg. Description: White, flat, rimmed tablet marked G00. Presentation: €6.31. Indication: Emergency contraception within 72 hours of unprotected sexual intercourse or failure of a contraceptive method. Pharmacology: Levonorgestrel is thought to work mainly by preventing ovulation and […]

Pentasa Sachet 4g

Company: Ferring Ireland Ltd. Legal category: Prescription. GMS. Sport permitted. Active ingredient: Mesalazine 4g. Description: White-grey to pale white-brown prolonged-release granules in sachet. Presentation: 30, €90.28. Indication: Mild to moderate ulcerative colitis. Pharmacology: Mesalazine is the active component of sulfasalazine. It inhibits leukocyte chemotaxis, decrease cytokine and leukotriene production and scavenge for free radicals. The […]

Treatment Adherence and Relapse Prevention in First-Episode Schizophrenia: Role of Long-Acting Injectable Antipsychotics

Download PDF There is growing evidence that long-acting injectable antipsychotics (LAIs) may be more effective for maintaining treatment adherence, reducing the rate of relapse and rehospitalisation, and preserving brain function, compared with oral antipsychotics, in first-episode or recent-onset schizophrenia. Given that the rates of nonadherence to antipsychotics are particularly high during the critical period of […]

Ivabradine (Procoralan) – New contraindication and recommendations to minimise the risk of cardiovascular events and severe bradycardia

The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAC) recently concluded its review of ivabradine (Procoralan) and has made recommendations aimed at reducing the risk of adverse cardiac effects, including myocardial infarction and bradycardia in patients being treated for symptomatic chronic stable angina in coronary artery disease. This review was initiated in May 2014 following […]

Harvoni ▼

Company: Gilead Sciences Ltd. Legal category: Prescription. Hospital only. Sport permitted. Active ingredient: Ledipasvir/sofosbuvir 90/400mg. Description: Orange, diamond-shaped, film-coated tablet marked GSI on one side and 7985 on reverse. Presentation: 28, price available on request. Indications: Treatment of chronic hepatitis C in patients with genotypes 1, 3 or 4. Pharmacology: Ledipasvir is a HCV inhibitor […]

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