Prostate cells depend on androgens to stimulate growth, function and proliferation. Testosterone secretion is regulated by the hypothalamic-pituitary-gonadal axis. Hypothalamic luteinising hormone-releasing hormone (LHRH) stimulates the anterior pituitary gland to release luteinising hormones (LH and FSH) stimulate the testes to secrete testosterone. Testosterone, although not tumorigenic, is also essential for the growth and perpetuation of [...]
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Download Pdf: MIMS Clinical Special – Table indications for hormonal therapy Table 2: Indications for hormonal therapy Hormonal therapy Indications for castration Benefits LE M1 symptomatic To palliate symptoms and to reduce the risk for potentially catastrophic sequelae of advanced disease (spinal cord compression, pathological fractures, ureteral obstruction, extraskeletal metastasis). 1b Even without a controlled [...]
Methylphenidate-Containing Medicines – availability of web-based educational tools Methylphenidate* is a CNS stimulant currently authorised in Ireland as part of a comprehensive programme for the treatment of attention-deficit hyperactivity disorder (ADHD) in children 6 years of age and over when remedial measures alone prove insufficient. The IMB previously highlighted issues associated with its use, most [...]
Lenalidomide (Revlimid) – risk of serious hepatic adverse reactions – routine monitoring of liver function now recommended Lenalidomide (Revlimid) is authorised in combination with dexamethasone for treatment of multiple myeloma in patients who have received at least one previous treatment. Lenalidomide is an immunomodulatory agent similar to thalidomide and has antineoplastic, antiangiogenic, and proerythropoietic properties. [...]
Company: Takeda Products Ireland Ltd. Legal category: Prescription. Hospital. Sport permitted. Active ingredient: Brentuximab vedotin 50mg. Description: Powder for concentrate for solution for infusion. Presentation: 50mg per vial, price available on request. Indications: Treatment of adults with relapsed or refractory CD30+ Hodgkin lymphoma following 1) autologous stem cell transplant (ASCT), or 2) at least 2 [...]
Company: Almirall Ltd. Legal category: Prescription. GMS. Sport permitted. Active ingredient: Almotriptan 12.5mg. Description: White, circular, biconvex film-coated tablet marked with a blue A on one side. Presentation: 3, €12.71; 6, €25.28; 9, €37.95. Indications: Acute treatment of the headache phase of migraine attacks with or without aura. Pharmacology: Almotriptan is a selective 5-HT1B and [...]
Company: Novartis Ireland Ltd. Legal category: Prescription. High Tech. Sport prohibited. Active ingredient: Epoetin alpha 20,000 IU/0.5ml, 30,000 IU/0.75ml. Description: Solution for injection in a pre-filled syringe. Presentation: 20,000 IU/0.5ml-6, €839.00; 30,000 IU/0.75ml-6, €1, 275.00. Indication: Treatment of anaemia and reduction of transfusion requirements in adults receiving chemotherapy for solid tumours, malignant lymphoma or multiple [...]
Company: Astellas Pharma Co. Ltd. Legal category: Prescription. High Tech. Sport permitted. Active ingredient: Fidaxomicin 200mg. Description: White to off white, capsule-shaped, film-coated tablets marked FDX on one side and 200 on reverse. Presentation: 20, €1,500. Indications: Treatment of Clostridium difficile infections (CDI). Pharmacology: Fidaxomicin belongs to the macrocyclic class of antibacterials. It works by [...]
Company: Meda Health Sales. Legal category: Prescription. GMS. Sport permitted. Active ingredients: Azelastine hydrochloride/fluticasone propionate 137mcg/50mcg per actuation. Description: Nasal spray, suspension. Presentation: 23g, €19.75. Indications: Relief of symptoms of moderate to severe seasonal and perennial allergic rhinitis if monotherapy with either intranasal antihistamine or glucocorticoid not considered sufficient. Pharmacology: Fluticasone propionate is a synthetic [...]
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