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November 27, 2015

Type 2 Diabetes and Insulin Therapy – ADA-EASD Guidelines 2015

Download PDF Key Recommendations on Management of Type 2 Diabetes Individualise glycaemic targets and glucose-lowering therapies. Diet, exercise, and education remain the foundation of all type 2 diabetes treatment programmes. Metformin is the optimal first-line drug in the absence of contraindications. After metformin, it is reasonable to consider combination therapy with an additional 1-2 oral […]

Donepezil – Reports of Rhabdomyolysis

Donepezil* is a specific and reversible inhibitor of acetylcholinesterase which has been authorised in Ireland since 1997 for use for the symptomatic treatment of mild to moderately severe Alzheimer’s dementia.   Reports of rhabdomyolysis associated with donepezil were recently reviewed by the EMA’s Pharmacovigilance Risk Assessment Committee (PRAC). Rhabdomyolysis is a clinical and biochemical syndrome […]

Risk of diabetic ketoacidosis during treatment with SGLT2 inhibitors

SGLT2 inhibitors include canagliflozin, dapagliflozin and empagliflozin alone or in combination with metformin, which are authorised for the treatment of type 2 diabetes mellitus.   Serious and sometimes life-threatening cases of diabetic ketoacidosis in patients treated with SGLT2 inhibitors have been reported, the majority of which required hospitalisation. Up to half of these cases occurred […]

Altavita D3

Company: Consilient Health Ltd. Legal category: Prescription. GMS reimbursable. Sport permitted. Active ingredient: Colecalciferol (vitamin D3) 25000 IU/ml. Description: Oral solution. Presentation: 3 X 1 ampoules, €5.56. Indications: Prevention and treatment of vitamin D deficiency. As an adjunct to specific therapy for osteoporosis. Pharmacology: Vitamin D stimulates intestinal calcium absorption, incorporation of calcium into the […]


Company: ALK-Abello Ltd. Legal category: Prescription. GMS reimbursable. Sport prohibited in competition. Active ingredient: Adrenaline (tartrate) 150mcg/ 0.15ml, 300mcg/ 0.30ml. Description: Solution for injection in pre-filled pen. Presentation: 1, €32.79. Indications: Emergency treatment of anaphylaxis caused by insect stings/bites, foods, drugs and other allergens as well as idiopathic or exercise induced anaphylaxis. Pharmacology: Adrenaline is […]

Spiolto Respimat

Company: Boehringer Ingelheim Ltd. Legal category: Prescription. Sport prohibited. GMS reimbursable. Active ingredients: Tiotropium (bromide monohydrate)/ olodaterol (hydrochloride) 2.5/2.5mcg per puff. Description: Inhalation solution. Presentation: 30 dose unit, €42.00. Indication: Maintenance bronchodilator treatment of chronic obstructive pulmonary disease (COPD). Pharmacology: Tiotropium bromide and olodaterol (LAMA/ LABA combination) provide additive bronchodilation due to their different modes […]

Synjardy ▼

Company: Boehringer Ingelheim Ltd. Legal category: Prescription. GMS reimbursable. Sport permitted. Active ingredients: Empagliflozin/metformin hydrochloride 5/850mg, 5/1000mg, 12.5/850mg, 12.5/1000mg. Description: Yellowish white, brownish yellow, pinkish white or dark brownish purple, oval, biconvex film coated tablets marked with S5 or S12 and logo on one side and strength on reverse. Presentation: 56, €42.00. Indications: Treatment of […]


Company: Santen. Legal category: Prescription. GMS reimbursable. Sport prohibited in specific sports. Active ingredients: Tafluprost/timolol (as maleate) 15mcg/5mg per ml. Description: Preservative-free, sterile, eye drops. Presentation: 0.3ml-30 single-dose units, €19.50. Indications: Reduction of intraocular pressure (IOP) in open angle glaucoma or ocular hypertension in patients insufficiently responsive to topical monotherapy with beta-blockers or prostaglandin analogues […]

Overview of Disease-Modifying Treatments in Multiple Sclerosis

Download PDF Diagnosis of Multiple Sclerosis Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating, degenerative disease of the central nervous system (CNS). During the early phases of the disease, the integrity of the blood-brain barrier (BBB) is compromised, permitting the invasion of monocytes and T cells into the brain parenchyma, resulting in the demyelination characteristic […]

Proton Pump Inhibitors (PPIs) – very rare reports of subacute cutaneous lupus erythematosus (SCLE)

Proton pump inhibitors (PPIs)* are indicated in the treatment of gastric and duodenal ulcers, NSAID-associated ulcers, gastro-oesophageal reflux, Zollinger-Ellison syndrome and in combination with antibacterial therapy for eradication of Helicobacter pylori. Some products are indicated for short-term use to treat reflux symptoms in adults (see individual SmPCs on www.hpra.ie for full details of licensed indications). […]

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