Despite older tricyclic antidepressants demonstrating a significantly greater efficacy over newer drugs, a major 30-year meta-analysis concludes the differences are largely a result of changes in trial designs, leading to greater placebo response and lower drug response.
The idea that patients who present with medication-resistant depression could be harbouring a hidden bipolar disorder has been bolstered by the largest study of the topic so far.
The adverse side effects of most neuromodulators and muscle relaxants overshadow any pain relief potential in rheumatoid arthritis (RA), a new Cochrane Review finds.
Most people with borderline personality disorder (BPD) are not violent, contrary to the overwhelming body of research, which has unduly focused on those already in the justice system, a systematic review has found.
Depression or a history of suicide attempts in young adults substantially increases their risk of dying from heart disease, an American study has found, and the risks are particularly marked for women.
New research shows people with bipolar disorder — and siblings of people with schizophrenia and bipolar disorder — are more likely to work in creative professions. The study lends further support to the commonly-held view that creativity is associated with mental disorder.
Using cannabis can lead to a loss of brain volume in people who are at risk of developing schizophrenia, according to a new study.
Dr Abdul Nasir Khalil and Dr Sabina Fahy look at the delicate issue of deciding when to stop driving after a diagnosis of dementia is made.
A new study has for the first time in humans linked levels of leptin, a hormone produced by fat cells, with symptoms of depression and anxiety, independent of weight.
Australian research shows that high levels of the inflammatory marker interleukin-12 are linked to impaired cognition in elderly people, particularly in women.
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