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Clinical Times: Diabetes
All entries for Diabetes
Avoiding nocturnal hypoglycaemia in children
09 March 2010
Closed-loop systems that link continuous glucose measurements to insulin delivery could reduce risk of nocturnal hypoglycaemia in children and adolescents with type I diabetes, new research has found. A team led by Dr Roman Hovorka of the Institute of Metabolic... Read more
Evaluating continuous monitoring of glucose
Gary Culliton | 05 March 2010
Clinical Update: Type 1 Diabetes - A continuous glucose monitoring system (CGMS) uses a sensor that is inserted under the skin. It measures interstitial glucose levels, which have been shown to correlate well with plasma glucose – though there is... Read more
Hypoglycaemia fears alleviated as system predicts glucose falls
Gary Culliton | 05 March 2010
Clinical Update: Type 1 Diabetes - The biggest fear that that type I diabetics have, in their daily lives, is hypoglycaemia, says UCC-based Consultant Endocrinologist, Prof Brendan Buckley. This may compromise diabetic control significantly in many patients.... Read more
Diabetic control vital in pregnant women
Gary Culliton | 05 March 2010
Clinical Update: Type 1 Diabetes - Good glucose control before and during pregnancy makes a huge difference to pregnancy outcome. If a woman conceives during a period of poor diabetic control, poor pregnancy outcomes are more likely.... Read more
Quitting increases short-term diabetes risk
20 January 2010
Patients who quit cigarette smoking are at a higher risk of developing type 2 diabetes, a new study has found. Although quitting smoking reduces the risk of lung cancer and cardiovascular disease, the decision to quit does not come without... Read more
New drugs improve diabetes outlook
Gary Culliton | 15 January 2010
Clinical Update - Diabetes: It is a very exciting time for the management of type 2 diabetes. New medications are being used and they do make a difference, Dr Diarmuid Smith, Consultant Endocrinologist at Dublin’s Beaumont Hospital, believes.... Read more
Gastric bypass 'cures' diabetes?
Gary Culliton | 15 January 2010
Clinical Update - Diabetes: Bariatic surgeons have been aware for some time that the effects of bypass surgery on diabetes are dramatic. Traditionally, patients referred for such surgery have had a BMI of 35kg/m2 and above. Improvement has been observed... Read more
Peptide Humanin provides more clues to diabetes
Gary Culliton | 15 January 2010
Clinical Update - Diabetes: Two papers have recently been published on the mitochondrial peptide Humanin (HN), in relation to insulin action. This peptide has an effect on insulin sensitivity. It suppresses hepatic glucose production and increases glucose uptake into the... Read more
Using incretin drugs to manage type 2 diabetic patients
Dr Colin Davenport | 04 December 2009
Dr Colin Davenport examines the role of the incretin class of drugs in offering glycaemic control and weight loss in type 2 diabetic mellitus patients... Read more
New diabetes drug is 'best compound ever'
Niamh Mullen | 26 November 2009
Novo Nordisk presented the latest data on its new diabetes drug at the 45th Annual Meeting of the European Association for the Study of Diabetes (EASD). Niamh Mullen reports from Vienna... Read more
Psychiatric considerations in patients with diabetes
Drs Brian O’Shea, Catherine McCollam, Marjorie Stokes and John Yek | 19 November 2009
Drs Brian O’Shea, Catherine McCollam, Marjorie Stokes and John Yek discuss how diabetes mellitus can impact on a patient’s mental health and well-being... Read more
ESC study show niacin produces lipid benefits
Natalya Anderson | 12 November 2009
Natalya Anderson reports from the 2009 European Society of Cardiology Congress on the benefits of niacin in producing significant beneficial lipid/lipoprotein changes in Type 2 diabetes mellitus... Read more
'Watch this space': DPP-4 inhibitors in type 2 diabetes care
Niamh Mullen | 22 October 2009
Cutting-edge research on new drugs for type 2 diabetes was presented by Boehringer Ingleheim at the 45th Annual Meeting of the European Association for the Study of Diabetes (EASD). Niamh Mullen reports from Vienna... Read more
One less drink a day helps reduce diabetes risk
14 October 2009
Reducing sugar intake by the equivalent of one can of a soft drink per day and increasing fibre intake by the amount equivalent to one half cup of beans per day appears to improve risk factors associated with type 2... Read more
Diabetes care has changed
09 October 2009
CLINICAL UPDATE: DIABETES. The biggest expansion in sub-areas of medicine in recent years has probably occurred in diabetes. Dr Maeve Durkan, consultant endocrinologist at Portiuncula hospital, said the incretin therapy drugs have facilitated a major change in the last three... Read more
Gene marks higher risk of disease
09 October 2009
CLINICAL UPDATE: DIABETES. Insulin resistance: The authors of a new paper maintain they have identified a genetic variation that confers increased risk of diabetes. A recent paper in Nature Genetics reported a new risk locus, located near the Insulin Receptor... Read more
Kidney disease a complication in a third of cases
09 October 2009
CLINICAL UPDATE: DIABETES. Kidney complications: Kidney disease is a very serious complication: it affects about 35 per cent of patients with diabetes. There are both genetic and environmental cues involved. The aim of Sanna Lehtonen’s ERC project called DiaDrug at... Read more
Irish study shows abnormal tolerance
Gary Culliton | 09 October 2009
CLINICAL UPDATE: DIABETES. Gestational diabetes: One in 10 Irish women have abnormal glucose tolerance in pregnancy – 250 percent more than would have been predicted – according to a study that will be presented at the Irish Endocrine Society meeting... Read more
Diabetes drug linked to increased risk of heart failure
26 August 2009
Rosiglitazone, which is used to treat type 2 diabetes, is associated with an increased risk of heart failure and death among older patients compared to pioglitazone, a new study has concluded. In light of such findings, the study’s researchers have... Read more
Diabetes adds to death risk after heart attack
26 August 2009
Women may have a slightly higher risk of death than men in the 30 days after a heart attack or other acute coronary syndrome (ACS), largely because of their rate of diabetes and other complicating clinical factors. Researchers evaluated the... Read more
Intensive treatment lowers complications
19 August 2009
The rates of serious complications among individuals with type 1 diabetes appear lower than reported historically, especially when patients are treated intensively, according to new research. The report followed a study in which researchers reviewed findings from the Diabetes Control... Read more
Antipsychotic drugs increase hospital risk for diabetics
12 August 2009
Older patients with diabetes who take antipsychotic medications appear to have an increased risk of hospitalisation for hyperglycaemia, especially soon after beginning treatment, according to a new report. The report followed a study of 13,817 individuals aged 66 years or... Read more
Higher levels of protein lowers risk of diabetes
11 August 2009
Patients with higher levels of adiponectin, a protein that is produced in the body by fat cells and that has anti-inflammatory and insulin-sensitising properties, have an associated lower risk of type 2 diabetes — according to a new analysis of... Read more
Type 1 diabetes in children
June Shannon | 10 July 2009
June Shannon examines the reasons why growing numbers of children are developing type 1 diabetes and looks at the Irish situation, which is now being monitored through a national childhood diabetes register. A disturbing but incredibly important study in a... Read more
An all-in-one approach is necessary in the treatment of diabetes
Gary Culliton | 03 June 2009
Gary Culliton attended the recent BMJ masterclass in Dublin — given by Dr Diarmuid Smith, Consultant Endocrinologist at Beaumont Hospital — which discussed some targets which should be set for Type 2 diabetes. Dr Diarmuid Smith, Consultant Endocrinologist at Beaumont... Read more
Diabetes questions answered
Prof Greald Tomkin | 17 November 2008
Continuing our Ask the Consultant series, Prof Gerald Tomkin answers questions from general practitioners on diabetes and how best to treat the condition. 1. Is there a case for advocating earlier insulin introduction in the poorly controlled type 2 diabetic?... Read more
Low-fat diet does not reduce risk of diabetes, new study concludes
Archives of Internal Medicine 2008;168:1500-1511 | 19 August 2008
Eating a low-fat diet does not appear to be associated with any change in diabetes risk, according to a new study. In the study, researchers investigated the effects of eating a low-fat diet on diabetes risk in 48,835 post-menopausal women.... Read more
Managing chronic diseases in general practice surgeries
Dr Velma Harkins | 17 August 2008
Dr Velma Harkins writes that our ageing demographic will mean a consequent increase in chronic diseases and that these must be managed in general practice Chronic diseases tend to be complex conditions in how they are caused. They are often... Read more
Sugar-sweetened beverages associated with diabetes risk
Archives of Internal Medicine 2008;168:1487-1492 | 09 August 2008
Drinking more soft drinks and fruit drinks is associated with an increased risk for diabetes, a new study has found. In the study, researchers examined the association between type 2 diabetes, weight gain and the consumption of sugar-sweetened soft drinks... Read more
Reduced intake of fruit and vegetables linked to bigger diabetes risk
08 August 2008
Eating fewer fruits and vegetables may be associated with an increased risk of type 2 diabetes, according to a new study. In the study, researchers analyzed blood vitamin C levels and fruit and vegetable intake in 21,831 individuals who did... Read more
Raised level of protein is linked to risk of diabetes in elderly
JAMA 2008;300:182-188 | 01 August 2008
Having a higher than normal level of the protein fetuin-A is associated with an increased risk of the development of diabetes, according to a new study. In the study, doctors examined whether higher fetuin-A levels are associated with the occurrence... Read more
Diabetes drug link to slower progression of retinopathy
Archives of Ophthalmology | 02 July 2008
Patients with diabetes who take the medication rosiglitazone may be less likely to develop the eye disease proliferative diabetic retinopathy or to experience reductions in visual acuity, according to a new report. In the study, doctors reviewed the medical records... Read more
Study links TZDs to adverse effects
Arch. Intern. Med. | 26 June 2008
A study has linked thiazolidinediones (TZDs), which are used to treat diabetes, to serious adverse effects. The use of insulin-sensitising thiazolidinediones (pioglitazone, rosiglitazone, and troglitazone) for one year or more was associated with a two- to threefold rise in the... Read more
IMB warns of risk of adverse reactions with rosiglitazone
26 June 2008
The Irish Medicines Board is reminding healthcare professionals to note the precautions and contraindications when prescribing rosiglitazone. Avandia is a medicinal product authorised for use throughout the EU through the European licensing process for the treatment of type II diabetes.... Read more
Mediterranean diet can protect against diabetes
BMJ Online First | 13 June 2008
The traditional Mediterranean diet provides substantial protection against type 2 diabetes, according to a new study. Current evidence suggests that such a diet has a protective role in cardiovascular disease, but little is known about its role in the risk... Read more
Surgical procedures in diabetes treatment
Natalya Anderson | 24 April 2008
Irish Medical Times' UK correspondent Natalya Anderson on the case for transplantation and obesity surgery in the management of diabetes. Pancreas trans-plantation in uraemic diabetic patients may allow them to become insulin-independent as well as dialysis free, according to data... Read more
Lower BP and LDL-cholesterol benefits diabetes patients
18 April 2008
Patients with diabetes who reduced their blood pressure and LDL-cholesterol to below standard target levels had a greater decrease in carotid artery wall thickness, but they did not have a significant difference in cardiovascular disease events than patients who had... Read more
Extra vitamin D in early childhood cuts the risk of adult diabetes
01 April 2008
Vitamin D supplements in early childhood may ward off the development of type 1 diabetes in later life, new research has found. Type 1 diabetes is an autoimmune disorder, in which insulin-producing beta cells in the pancreas are destroyed by... Read more
Diabetes mellitus and gastrointestinal dysfunction
Dr Deirdre O'Donovan | 15 March 2008
Dr Deirdre O'Donovan, Consultant Gastroenterologist at the Hermitage Medical Clinic, examines the close link between gastrointestinal function and diabetes mellitus Diabetes mellitus and the gut are inextricably linked. The last 10-15 years has seen a redefinition of concepts relating to... Read more
Metformin and living changes hit antipsychotic drug weight-gains
JAMA 2008;299:185-193 | 18 January 2008
The diabetes drug metformin and lifestyle changes are effective against anti-psychotic-induced weight gain, and treatment is most effective when the two therapies are combined, according to a new study from China. In the past decade, there has been a growing... Read more
Glucose monitoring in Type 1 diabetes: past, present and future
Dr El-Muntasir El-Hadi & Dr Kevin B. Moore | 11 January 2008
Over the past 15 years we have come to understand the importance of tight glycaemic control in the care of patients with Type 1 diabetes. Through the Diabetes Control and Complications trial (DCCT) and the subsequent Epidemiology of Diabetes Interventions... Read more
Education, exercise and diet are needed to stop diabetes epidemic
Dr Mary Ryan | 30 November 2007
There is an alarming rise in obesity going hand in hand with an increase in Type 2 diabetes in Irish children and adolescents. Obviously, prevention must start early in life with very simple tools such as the facilitation of physical... Read more
Research suggests Omega 3 cuts childhood diabetes risk
JAMA 2007;298:1420-1428 | 26 October 2007
Preliminary research has suggested that for children at increased risk for type 1 diabetes, dietary intake of omega-3 fatty acids was associated with a reduced risk of pancreatic islet autoimmunity. In the study, American researchers, examined whether consumption of omega-3... Read more
Future trends in treating obesity
Prof Gerald H Tomkin, Consultant Physician | 19 October 2007
The tremendous interest in weight, diabetes and obesity continues unabated. We are watching a world that is rapidly increasing in weight and has little idea of how to reverse the trend. The major increase is found in people from underdeveloped... Read more
Food supplements to treat diabetes and atherosclerosis
14 September 2007
The health benefits of cutting down on dietary saturated fatty acids and including higher levels of unsaturated fatty acids are well documented in medical literature. Nutritional research is focusing on the effects of incorporating these healthier fatty acids, such as... Read more
Heart attack patients at higher risk of developing diabetes
The Lancet | 07 September 2007
People who have had heart attacks are at higher risk of developing both new-onset diabetes and impaired fasting glucose (IFG), a new study has found. In the study, doctors investigated 8,291 Italian patients who had had a heart attack within... Read more
DNA-based vaccine for treatment of diabetes
Archives of Neurology | 31 August 2007
A newly developed DNA-based vaccine appears safe and effective against multiple sclerosis, according to a new study. If the study’s results are confirmed in a follow-up clinical trial already under way, the study’s researchers believe that DNA-based vaccines can be... Read more
Diabetics with ACS at greater risk of dying
JAMA | 31 August 2007
Individuals with diabetes and such acute coronary syndromes (ACS) as heart attack and unstable angina have an increased risk of death at 30 days and one year after ACS, compared with ACS patients without diabetes, according to a new study.... Read more
Diabetes takes profound toll on quality of life
BMC Public Health | 10 August 2007
A new Greek study has found that diabetes and its complications can take a profound toll on quality of life in the elderly. Greek doctors attempted to assess health-related quality of life of Type 2 diabetes patients and to identify... Read more
Obesity increase in Ireland is driving type 2 diabetes
Dr Mary Ryan | 03 August 2007
Obese children and adolescents are at increased risk for the development of insulin resistance and the subsequent development of type 2 diabetes, hypertension, dyslipidaemia, metabolic syndrome, cardiovascular disease and other disorders. For most of the 20th century cardiovascular disease was... Read more
Medications may provide diabetes treatment option
JAMA | 03 August 2007
A review of previous studies indicates that use of so-called “incretin-based therapy,” which acts via certain pathways that affect glucose metabolism, may provide modest effectiveness and favourable weight change outcomes for the treatment of type 2 diabetes and may represent... Read more
Tackling the diabetes dilemma requires sharing the burden
Dr Mary Ryan | 27 July 2007
The Health Promotion and Care of Patients with Type II diabetes community pharmacy project was established by a Co-operation and Working Together (CAWT) cross-border working group with senior pharmaceutical services representatives from the Southern and Western Health and Social Services... Read more
Anti-malarial drug may reduce risk of diabetes in patients with arthritis
JAMA | 20 July 2007
Preliminary research suggests that use of the anti-malarial drug hydroxychloroquine may help reduce the risk of the development of diabetes in patients with rheumatoid arthritis. In the study, doctors examined the association between hydroxychloroquine therapy and risk of diabetes in... Read more
Pharmacists help patients to manage Type II diabetes
Colin Kerr | 13 July 2007
The Health Promotion and Care of Patients with Type II diabetes community pharmacy project was established by a Co-Operation and Working Together (CAWT) cross-border working group with senior pharmaceutical services representatives from the Southern and Western Health and Social Services... Read more
Taking pills to prevent diabetes cannot be justified by experts
BMJ 2007;334:822-824 | 11 May 2007
Taking prescription drugs to prevent diabetes cannot be justified, according to leading experts in the field. The experts, led by Prof Victor Montori at the Mayo Clinic in Rochester Minnesota, argued that lifestyle changes, such as modest weight loss and... Read more
Aggressive treatment of blood pressure and diet control needed
Dr Mary Ryan | 27 April 2007
Diabetic nephropathy is now a major cause of premature death in patients with all types of diabetes. Approximately one-sixth of patients entering renal replacement programmes in developed counties will now have diabetes, at least 50 per cent having type 2... Read more
Statin therapy continues to provide clinical benefit
Gary Culliton | 20 April 2007
The Collaborative Atorvastatin Diabetes Study (CARDS) showed a significant reduction in cardiovascular events in patients, Prof John Betteridge, a lead author of CARDS and Professor of Endocrinology and Metabolism at University College London Hospital, told the Pfizer Cardiovascular National Forum.... Read more
Diabetic retinopathy is the commonest cause of blindness
Dr Mary Ryan | 16 March 2007
The classic case of diabetic neuropathy is based on an ophthalmology examination but several other changes not seen microscopically may help to explain some of the findings. One of the first histological changes seen is thickening of the capillary base... Read more
Balancing the new with the old in treating diabetes, part two
Prof Gerald Tomkin | 02 March 2007
The ADOPT study (A Diabetes Outcome Progression Trial) was reported in The New England Journal of Medicine at the end of last year. The object of the study was to examine the efficacy of thiolazinediones as compared to other oral... Read more
Uncertainty still surrounds the treatment of diabetic patients, part one
Prof Gerald Tomkin | 23 February 2007
“To sleep perchance to dream.” This Shakespearean line may seem an unusual opening to an article on the treatment of type 2 diabetes but a discussion about such treatment in 2007 has to pay some attention to the DREAM (diabetes... Read more
An aggressive research agenda is needed to fight metabolic syndrome
Dr Mary Ryan | 16 February 2007
For most of the 20th century, cardiovascular disease was identified as the major cause of morbidity and mortality in the developed world. During this period considerable efforts were made to understand the underlying biology of the disease and to identify... Read more
ARBs and ACE inhibitors are least likely to lead to diabetes
The Lancet 2007;369:201-207 | 02 February 2007
Antihypertensive agents least associated with incident diabetes are angiotensin-receptor blockers (ARBs) and angiotensin-converting-enzyme inhibitors (ACE) are according to a new study. In the study, doctors undertook a network meta-analysis to assess the relative odds of developing diabetes during long-term treatment... Read more
Lifestyle changes effective in protecting against type II diabetes
BMJ | 02 February 2007
Changing to a healthier lifestyle appears to be at least as effective as taking prescription drugs in reducing the risk of developing Type 2 diabetes, a new UK study has found. Researchers from Leicester reviewed studies which measured the effects... Read more
New and better ways should be developed in managing hyperglycaemia
Prof Gerald H Tomkin | 19 January 2007
The past 20 years has seen some of the most amazing and exciting discoveries in many aspects of science and medicine. The understanding of basic physiology and pathology at a molecular level has resulted in the development of treatments that... Read more
EU charter aims to fight obesity
08 December 2006
The Irish Heart Foundation says the landmark European Charter on Counteracting Obesity has not got the coverage it deserves. Irish Medical Times prints an edited version of the document 1.1 The epidemic of obesity poses one of the most serious... Read more