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Clinical Times: January 2010
Depression — the real worldwide epidemic?
Dr Suzanne Milligan | 29 January 2010 | Mental Health & CNS
Depression Supplement: Dr Suzanne Milligan discusses depression as it typically presents in general practice and suggests that the condition, which is on the rise, needs extra vigilance... Read more
Diagnosis and treatment of GAD
Rory Hafford | 29 January 2010 | Mental Health & CNS
Depression Supplement: Rory Hafford puts generalised anxiety disorder under the microscope and discovers a wolf in sheep’s clothing... Read more
Depression, epigenetics and the ‘plastic brain’ — a GP’s view
Dr Harry Barry | 29 January 2010 | Mental Health & CNS
Depression Supplement: Dr Harry Barry takes a look at how developments in neuroscience have changed the ways in which we diagnose and treat conditions such as major depressive disorder... Read more
Treatment through talking
Rory Hafford | 29 January 2010 | Mental Health & CNS
Depression Supplement: Rory Hafford listens to the considerable treatment benefits of one of the most effective talk therapies, cognitive behavioural therapy... Read more
Update on treatment options
Gary Culliton | 28 January 2010 | Respiratory
Clinical update: COPD & Asthma - The main underlying problem with asthma is airways inflammation, which leads to asthma symptoms and reduced lung function. Inhaled steroids are generally the main initial therapy for many asthmatics.... Read more
Quitting is crucial in managing COPD
Gary Culliton | 28 January 2010 | Respiratory
Clinical update: COPD & Asthma - A total of 85-90 per cent of people who develop chronic obstructive pulmonary disease (COPD) are smokers, the Asthma Society of Ireland reports. COPD is a growing problem and about 30 per cent of... Read more
Genetic mutation may predispose to asthma
Gary Culliton | 28 January 2010 | Respiratory
Clinical update: COPD & Asthma - Mutations in the filaggrin gene among many Irish families predisposes them to develop eczema and this may progress later to asthma, revealed Prof Padraic Fallon, Science Foundation Ireland Stokes Professor of Translational Immunology at... Read more
Researchers study immune system's role in triggering asthma
Gary Culliton | 28 January 2010 | Respiratory
Clinical update: COPD & Asthma - There has been a confluence of two advances in asthma, said Dr Conor Burke, Respiratory Consultant at Connolly Hospital in Blanchardstown.... Read more
The Endocrinology Clinic: Hirsutism
Prof T Joseph McKenna and Dr Frances Hayes | 28 January 2010 | Women's Health
Continuing their series on ‘Notes from the Endocrinology Clinic’, Prof T Joseph McKenna and Prof Frances Hayes examine the causes and treatment options available for hirsutism... Read more
Antibiotic doses should be adjusted for bodyweight
27 January 2010 | Infections & Immunology
Doses of antibiotics and other antimicrobial agents should take into account the patient’s bodyweight, to maximise their potential effectiveness, according to leading Greek researchers. “For most widely used antimicrobial agents, dosing recommendations in adults do not take into account adjustment... Read more
High rate of drug errors during treatment of children in hospital
27 January 2010 | Paediatrics
Mistakes are being made in a high number of drug treatments given to children in hospital, either when prescribing or administering the medicines, new study has revealed. Although most of the mistakes were unlikely to cause serious harm, a small... Read more
Discouraging flowers from hospitals not cut and dried
27 January 2010 | Infections & Immunology
Researchers in Britain have questioned the recent decisions by some hospitals there to ban flowers. Researchers from Imperial College London surveyed the literature and talked to patients and staff at the Royal Brompton Hospital and the Chelsea & Westminster Hospital... Read more
Jury still out on e-cigarettes
27 January 2010 | Cardiovascular
More research is needed before consumers can be reassured that electronic cigarettes (e-cigarettes) are safe, according to two leading experts. Andreas Flouris and Dimitris Oikonomou, from the Institute of Human Performance and Rehabilitation in Greece, wrote that say that ‘our... Read more
Medication is available to treat Alzheimer's disease
Gary Culliton | 22 January 2010 | Mental Health & CNS
Clinical Update - Alzheimer's: Evidence from clinical trials show that the behavioural disturbance features of Alzheimer’s disease (AD) can be helped. A subset of patients with dementia can experience significant behavioural disturbance, and it can completely alter their personality.... Read more
Pathways research may help AD
Gary Culliton | 22 January 2010 | Mental Health & CNS
Clinical Update - Alzheimer's: It is thought that in Alzheimer’s disease, accumulations of amyloid deposits (amyloid-beta, known as Ab) destroy synapses, the major communication networks in the brain.... Read more
Scans hold potential to observe ‘moving target’ of degeneration
Gary Culliton | 22 January 2010 | Mental Health & CNS
Clinical Update - Alzheimer's: With the emergence of scan technology over the past 20 years, medics have the potential to investigate the living brain, allowing the ‘moving target’ of degeneration to be observed. Thus the ability of pharmacological treatments to... Read more
Treatment to delay disease progression in pipeline
Gary Culliton | 22 January 2010 | Mental Health & CNS
Clinical Update - Alzheimer's: Senior Research Fellow at TCD’s Institute of Neuroscience Dr Michael Ewers believes that as there are so many different compounds in the pipeline, the expectation is that in the near future, a potential treatment to delay... Read more
The Endocrinology Clinic: PCOS
Dr Frances Hayes and Prof T Joseph McKenna | 21 January 2010 | Women's Health
Continuing their series on ‘Notes from the Endocrinology Clinic’, Dr Frances Hayes and Prof T Joseph McKenna examine polycystic ovary syndrome... Read more
Programme may help prevent knee injuries in soccer players
20 January 2010 | Musculoskeletal
A soccer-specific exercise programme that includes individual instruction of athletes appears to reduce the risk of knee injuries in young female players, according to a new Swedish study. In the study, doctors assessed an intervention programme specifically designed to reduce... Read more
Exercise can reduce risk of mild cognitive impairment — study
20 January 2010 | Cardiovascular
Moderate physical activity performed in midlife or later appears to be associated with a reduced risk of mild cognitive impairment, whereas a six-month high-intensity aerobic exercise programme may improve cognitive function in individuals who already have the condition, according to... Read more
Quitting increases short-term diabetes risk
20 January 2010 | Diabetes
Patients who quit cigarette smoking are at a higher risk of developing type 2 diabetes, a new study has found. Although quitting smoking reduces the risk of lung cancer and cardiovascular disease, the decision to quit does not come without... Read more
Bifocals may slow progression of nearsightedness
20 January 2010 | Eye, Ear, Nose & Throat
Bifocal glasses may be effective in slowing the progression of myopia in children with high rates of progression, according to a new report. The report followed a study in which doctors conducted a randomised, controlled clinical trial among 135 Chinese-Canadian... Read more
New drugs improve diabetes outlook
Gary Culliton | 15 January 2010 | Diabetes
Clinical Update - Diabetes: It is a very exciting time for the management of type 2 diabetes. New medications are being used and they do make a difference, Dr Diarmuid Smith, Consultant Endocrinologist at Dublin’s Beaumont Hospital, believes.... Read more
Gastric bypass 'cures' diabetes?
Gary Culliton | 15 January 2010 | Diabetes
Clinical Update - Diabetes: Bariatic surgeons have been aware for some time that the effects of bypass surgery on diabetes are dramatic. Traditionally, patients referred for such surgery have had a BMI of 35kg/m2 and above. Improvement has been observed... Read more
Peptide Humanin provides more clues to diabetes
Gary Culliton | 15 January 2010 | Diabetes
Clinical Update - Diabetes: Two papers have recently been published on the mitochondrial peptide Humanin (HN), in relation to insulin action. This peptide has an effect on insulin sensitivity. It suppresses hepatic glucose production and increases glucose uptake into the... Read more
The Endocrinology Clinic: Amenorrhoea
Dr Frances Hayes and Prof T Joseph McKenna | 14 January 2010 | Women's Health
In the first in a new series on ‘Notes from the Endocrinology Clinic’, Dr Frances Hayes and Prof T Joseph McKenna examine the causes and treatment options available for amenorrhoea... Read more
Doctors can RE-LY on new therapy
Rory Hafford | 14 January 2010 | Cardiovascular
Rory Hafford finds out from the RE-LY trial that dabigatran is the new therapeutic advance in stroke prevention that patients and treating physicians have been waiting on for decades... Read more
HPV vaccine offers sustained protection
13 January 2010 | Infections & Immunology
The Cervarix human papilloma virus (HPV) vaccine from GlaxoSmithKline offers sustained protection beyond six years from infection against the types of HPV most commonly associated with cervical cancer (HPV-16 and HPV-18). According to background information supplied by the study’s authors,... Read more
Smoking cessation in CVD patients effective
13 January 2010 | Cardiovascular
Varenicline, a partial alpha4beta2 nicotinic acetylcholine receptor agonist, is effective for smoking cessation in smokers with cardiovascular disease (CVD), a new limited study has suggested. Researchers at the Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston carried out a... Read more
New computerised weighing scale targets childhood obesity rate
13 January 2010 | Nutrition
A new computerised device that tracks portion size and how fast people eat is more successful in helping obese children and adolescents lose weight than standard treatments, according to research in the BMJ. The Mandometer device, a portable computerised weighing... Read more
Reduction in infection risk with POP patients
13 January 2010 | Infections & Immunology
Broad-spectrum antibiotics should be used in intensive care unit (ICU) patients with post-operative peritonitis (POP) who have received antimicrobial therapy in the three months prior to hospitalisation, new research has suggested. The team from Rennes, France also said such treatment... Read more
New guidelines reduce antibiotic use
07 January 2010 | Infections & Immunology
The use of guidelines for treatment of lower respiratory tract infections (LRTIs) such as bronchitis and pneumonia determined by measurements of procalcitonin (PCT) resulted in lower rates of antibiotic use and associated adverse effects, and similar rates of adverse outcomes... Read more
Costs of Mediterranean diet may put people off
07 January 2010 | Nutrition
Mediterranean diets may be healthier, but they also trim the wallet, which may put people off, a new study has suggested. Researchers assessed the dietary patterns of more than 11,000 Spanish university graduates in 2008.... Read more
Three-day course of antibiotics as effective after tonsillectomy
05 January 2010 | Infections & Immunology
Children who receive a three-day course of antibiotics following tonsillectomy rather than a seven-day course appear to have no differences in pain or how quickly they return to a normal diet and activity level, according to a new report. The... Read more
Myopia has become more common
05 January 2010 | Eye, Ear, Nose & Throat
Myopia may be more common now than 30 years ago, according to a new report. Researchers in the US compared American population prevalence estimates for myopia from the National Health and Nutrition Examination Survey (NHANES) in 4,436 black and white... Read more
