Significant Benefits of Bedtime Therapy Variation in blood pressure levels display circadian rhythms, with a morning surge in blood pressure (BP) known to increase the risk of myocardial events in the first several hours post awakening. Time of ingestion of hypertension medications can affect this circadian pattern of BP, and there is emerging evidence that [...]
2011 NICE Hypertension Guidelines Updated NICE guidelines on hypertension1, published in October last year in conjunction with the British Hypertension Society (BHS), recommend that a diagnosis of hypertension should be made using 24-hour ambulatory blood pressure monitoring (ABPM). The process involves wearing a type of mobile blood pressure monitor that straps around the waist and [...]
Lucentis (ranibizumab) is now approved to treat visual impairment due to macular oedema secondary to retinal vein occlusion (including branch RVO or central RVO). Retinal vein occlusion (RVO) is the second most common retinal vascular disorder after diabetic retinopathy. Occlusion of the outflow channel of the retinal circulation markedly increases intraluminal venous pressure, resulting in [...]
Products include: Cipramil/Bellcital/Ciprager/Ciprapine/Ciprotan/Citalopram Actavis/Citalopram Teva/ Citrol and Lexapro/Escipriex/Escitalpro/Escitomar Citalopram and escitalopram are selective serotonin reuptake inhibitors (SSRIs) indicated in the treatment of depressive illness (see the Summaries of Product Characteristics (SPCs) for full details of licensed indications). Following a review of the available information on the risk of QT prolongation with these medicines, the Pharmacovigilance [...]
Adapted from the presentation ‘COPD – Where are we now?’, which took place at the Frontiers in Respiratory Medicine meeting, October 21st, 2011. MIMS Ireland Copyright®
Prevalence Moderate and Severe COPD affects one in 10 people The prevalence of COPD is increasing in Ireland, and COPD is expected to be the third cause of death by 2020. BOLD, a worldwide study including close to 10,000 participants, aimed to measure the prevalence of COPD, its risk factors and their variation across countries [...]
Towards endotype-specific therapy Phenotypes vs Endotypes One way to classify asthma involves identifying the phenotypes of asthma – that is the clusters of properties observed in different types of asthma. Criteria related to clinical aspects (e.g. severity and frequency of exacerbations, airflow restriction, age of onset, treatment effect), type of inflammatory cells (eosinophils or neutrophils) [...]
Products include Domerid/Motilium Domperidone is a propulsive agent and a dopamine antagonist with antiemetic properties. It is authorised for use in adults for the relief of nausea and vomiting, epigastric sense of fullness, upper abdominal discomfort and regurgitation of gastric contents, and in children for the relief of nausea and vomiting. The risk of QTc [...]
The World Anti-Doping Code, published by the World Anti-Doping Agency (WADA), harmonises anti-doping regulations across all sports and in all countries. This Code includes a list of substances and methods which are prohibited in sport. Some of these substances are contained in medicinal products marketed in Ireland. However, in recognition of the fact that some [...]
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